Thioredoxin, Glutathione and Related Molecules in Tumors of the Nervous System.
Identifieur interne : 000007 ( Main/Exploration ); précédent : 000006; suivant : 000008Thioredoxin, Glutathione and Related Molecules in Tumors of the Nervous System.
Auteurs : Vasco Branco [Portugal] ; José Pimentel [Portugal] ; Maria Alexandra Brito [Portugal] ; Cristina Carvalho [Portugal]Source :
- Current medicinal chemistry [ 1875-533X ] ; 2020.
Descripteurs français
- KwdFr :
- MESH :
English descriptors
- KwdEn :
- MESH :
- chemical : Glutathione, Thioredoxin-Disulfide Reductase, Thioredoxins.
- Humans, Neoplasms, Oxidation-Reduction.
Abstract
BACKGROUND
Central Nervous System (CNS) tumors have a poor survival prognosis due to their invasive and heterogeneous nature, in addition to the resistance to multiple treatments.
OBJECTIVE
In this paper, the main aspects of brain tumor biology and pathogenesis are reviewed both for primary tumors of the brain, (i.e., gliomas) and for metastasis from other malignant tumors, namely lung cancer, breast cancer and malignant melanoma which account for a high percentage of overall malignant brain tumors. We review the role of antioxidant systems, namely the thioredoxin and glutathione systems, in the genesis and/or progression of brain tumors.
METHODS
Although overexpression of Thioredoxin Reductase (TrxR) and Thioredoxin (Trx) is often linked to increased malignancy rate of brain tumors, and higher expression of Glutathione (GSH) and Glutathione S-Transferases (GST) are associated to resistance to therapy, several knowledge gaps still exist regarding for example, the role of Peroxiredoxins (Prx), and Glutaredoxins (Grx).
CONCLUSION
Due to their central role in redox homeostasis and ROS scavenging, redox systems are potential targets for new antitumorals and examples of innovative therapeutics aiming at improving success rates in brain tumor treatment are discussed.
DOI: 10.2174/0929867326666190201113004
PubMed: 30706774
Affiliations:
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Prof. Gama Pinto, 1649-003 Lisboa, Portugal.</nlm:affiliation><country xml:lang="fr">Portugal</country><wicri:regionArea>Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Av. Prof. Gama Pinto, 1649-003 Lisboa</wicri:regionArea><wicri:noRegion>1649-003 Lisboa</wicri:noRegion></affiliation></author><author><name sortKey="Pimentel, Jose" sort="Pimentel, Jose" uniqKey="Pimentel J" first="José" last="Pimentel">José Pimentel</name><affiliation wicri:level="1"><nlm:affiliation>Laboratory of Neuropathology, Department of Neurology, Hospital de Santa Maria (CHLN), Av. Prof. Egas Moniz, 1649-036 Lisboa, Portugal.</nlm:affiliation><country xml:lang="fr">Portugal</country><wicri:regionArea>Laboratory of Neuropathology, Department of Neurology, Hospital de Santa Maria (CHLN), Av. Prof. Egas Moniz, 1649-036 Lisboa</wicri:regionArea><wicri:noRegion>1649-036 Lisboa</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Faculty of Medicine, Lisbon University, Av. Prof. Egas Moniz, 1649-036 Lisboa, Portugal.</nlm:affiliation><country xml:lang="fr">Portugal</country><wicri:regionArea>Faculty of Medicine, Lisbon University, Av. Prof. Egas Moniz, 1649-036 Lisboa</wicri:regionArea><wicri:noRegion>1649-036 Lisboa</wicri:noRegion></affiliation></author><author><name sortKey="Brito, Maria Alexandra" sort="Brito, Maria Alexandra" uniqKey="Brito M" first="Maria Alexandra" last="Brito">Maria Alexandra Brito</name><affiliation wicri:level="1"><nlm:affiliation>Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Av. Prof. Gama Pinto, 1649-003 Lisboa, Portugal.</nlm:affiliation><country xml:lang="fr">Portugal</country><wicri:regionArea>Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Av. Prof. Gama Pinto, 1649-003 Lisboa</wicri:regionArea><wicri:noRegion>1649-003 Lisboa</wicri:noRegion></affiliation></author><author><name sortKey="Carvalho, Cristina" sort="Carvalho, Cristina" uniqKey="Carvalho C" first="Cristina" last="Carvalho">Cristina Carvalho</name><affiliation wicri:level="1"><nlm:affiliation>Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Av. Prof. Gama Pinto, 1649-003 Lisboa, Portugal.</nlm:affiliation><country xml:lang="fr">Portugal</country><wicri:regionArea>Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Av. Prof. Gama Pinto, 1649-003 Lisboa</wicri:regionArea><wicri:noRegion>1649-003 Lisboa</wicri:noRegion></affiliation></author></analytic><series><title level="j">Current medicinal chemistry</title><idno type="eISSN">1875-533X</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Glutathione (MeSH)</term><term>Humans (MeSH)</term><term>Neoplasms (MeSH)</term><term>Oxidation-Reduction (MeSH)</term><term>Thioredoxin-Disulfide Reductase (MeSH)</term><term>Thioredoxins (MeSH)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Glutathion (MeSH)</term><term>Humains (MeSH)</term><term>Oxydoréduction (MeSH)</term><term>Thioredoxin-disulfide reductase (MeSH)</term><term>Thiorédoxines (MeSH)</term><term>Tumeurs (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Glutathione</term><term>Thioredoxin-Disulfide Reductase</term><term>Thioredoxins</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Humans</term><term>Neoplasms</term><term>Oxidation-Reduction</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Glutathion</term><term>Humains</term><term>Oxydoréduction</term><term>Thioredoxin-disulfide reductase</term><term>Thiorédoxines</term><term>Tumeurs</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>BACKGROUND</b></p><p>Central Nervous System (CNS) tumors have a poor survival prognosis due to their invasive and heterogeneous nature, in addition to the resistance to multiple treatments.</p></div><div type="abstract" xml:lang="en"><p><b>OBJECTIVE</b></p><p>In this paper, the main aspects of brain tumor biology and pathogenesis are reviewed both for primary tumors of the brain, (i.e., gliomas) and for metastasis from other malignant tumors, namely lung cancer, breast cancer and malignant melanoma which account for a high percentage of overall malignant brain tumors. We review the role of antioxidant systems, namely the thioredoxin and glutathione systems, in the genesis and/or progression of brain tumors.</p></div><div type="abstract" xml:lang="en"><p><b>METHODS</b></p><p>Although overexpression of Thioredoxin Reductase (TrxR) and Thioredoxin (Trx) is often linked to increased malignancy rate of brain tumors, and higher expression of Glutathione (GSH) and Glutathione S-Transferases (GST) are associated to resistance to therapy, several knowledge gaps still exist regarding for example, the role of Peroxiredoxins (Prx), and Glutaredoxins (Grx).</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSION</b></p><p>Due to their central role in redox homeostasis and ROS scavenging, redox systems are potential targets for new antitumorals and examples of innovative therapeutics aiming at improving success rates in brain tumor treatment are discussed.</p></div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" IndexingMethod="Curated" Owner="NLM"><PMID Version="1">30706774</PMID><DateCompleted><Year>2020</Year><Month>07</Month><Day>08</Day></DateCompleted><DateRevised><Year>2020</Year><Month>07</Month><Day>08</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1875-533X</ISSN><JournalIssue CitedMedium="Internet"><Volume>27</Volume><Issue>12</Issue><PubDate><Year>2020</Year></PubDate></JournalIssue><Title>Current medicinal chemistry</Title><ISOAbbreviation>Curr Med Chem</ISOAbbreviation></Journal><ArticleTitle>Thioredoxin, Glutathione and Related Molecules in Tumors of the Nervous System.</ArticleTitle><Pagination><MedlinePgn>1878-1900</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.2174/0929867326666190201113004</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Central Nervous System (CNS) tumors have a poor survival prognosis due to their invasive and heterogeneous nature, in addition to the resistance to multiple treatments.</AbstractText><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">In this paper, the main aspects of brain tumor biology and pathogenesis are reviewed both for primary tumors of the brain, (i.e., gliomas) and for metastasis from other malignant tumors, namely lung cancer, breast cancer and malignant melanoma which account for a high percentage of overall malignant brain tumors. We review the role of antioxidant systems, namely the thioredoxin and glutathione systems, in the genesis and/or progression of brain tumors.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">Although overexpression of Thioredoxin Reductase (TrxR) and Thioredoxin (Trx) is often linked to increased malignancy rate of brain tumors, and higher expression of Glutathione (GSH) and Glutathione S-Transferases (GST) are associated to resistance to therapy, several knowledge gaps still exist regarding for example, the role of Peroxiredoxins (Prx), and Glutaredoxins (Grx).</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">Due to their central role in redox homeostasis and ROS scavenging, redox systems are potential targets for new antitumorals and examples of innovative therapeutics aiming at improving success rates in brain tumor treatment are discussed.</AbstractText><CopyrightInformation>Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Branco</LastName><ForeName>Vasco</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Av. Prof. Gama Pinto, 1649-003 Lisboa, Portugal.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pimentel</LastName><ForeName>José</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Laboratory of Neuropathology, Department of Neurology, Hospital de Santa Maria (CHLN), Av. Prof. Egas Moniz, 1649-036 Lisboa, Portugal.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Faculty of Medicine, Lisbon University, Av. Prof. Egas Moniz, 1649-036 Lisboa, Portugal.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Brito</LastName><ForeName>Maria Alexandra</ForeName><Initials>MA</Initials><AffiliationInfo><Affiliation>Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Av. Prof. Gama Pinto, 1649-003 Lisboa, Portugal.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Carvalho</LastName><ForeName>Cristina</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Av. Prof. Gama Pinto, 1649-003 Lisboa, Portugal.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016454">Review</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United Arab Emirates</Country><MedlineTA>Curr Med Chem</MedlineTA><NlmUniqueID>9440157</NlmUniqueID><ISSNLinking>0929-8673</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>52500-60-4</RegistryNumber><NameOfSubstance UI="D013879">Thioredoxins</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 1.8.1.9</RegistryNumber><NameOfSubstance UI="D013880">Thioredoxin-Disulfide Reductase</NameOfSubstance></Chemical><Chemical><RegistryNumber>GAN16C9B8O</RegistryNumber><NameOfSubstance UI="D005978">Glutathione</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D005978" MajorTopicYN="N">Glutathione</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009369" MajorTopicYN="Y">Neoplasms</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010084" MajorTopicYN="N">Oxidation-Reduction</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013880" MajorTopicYN="N">Thioredoxin-Disulfide Reductase</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013879" MajorTopicYN="N">Thioredoxins</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Brain tumors</Keyword><Keyword MajorTopicYN="N">antioxidant systems</Keyword><Keyword MajorTopicYN="N">central nervous system</Keyword><Keyword MajorTopicYN="N">glioma</Keyword><Keyword MajorTopicYN="N">glutathione</Keyword><Keyword MajorTopicYN="N">thioredoxin.</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2017</Year><Month>09</Month><Day>28</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2018</Year><Month>09</Month><Day>14</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2018</Year><Month>11</Month><Day>28</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2019</Year><Month>2</Month><Day>2</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>7</Month><Day>9</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2019</Year><Month>2</Month><Day>2</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">30706774</ArticleId><ArticleId IdType="pii">CMC-EPUB-96286</ArticleId><ArticleId IdType="doi">10.2174/0929867326666190201113004</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Portugal</li></country></list><tree><country name="Portugal"><noRegion><name sortKey="Branco, Vasco" sort="Branco, Vasco" uniqKey="Branco V" first="Vasco" last="Branco">Vasco Branco</name></noRegion><name sortKey="Brito, Maria Alexandra" sort="Brito, Maria Alexandra" uniqKey="Brito M" first="Maria Alexandra" last="Brito">Maria Alexandra Brito</name><name sortKey="Carvalho, Cristina" sort="Carvalho, Cristina" uniqKey="Carvalho C" first="Cristina" last="Carvalho">Cristina Carvalho</name><name sortKey="Pimentel, Jose" sort="Pimentel, Jose" uniqKey="Pimentel J" first="José" last="Pimentel">José Pimentel</name><name sortKey="Pimentel, Jose" sort="Pimentel, Jose" uniqKey="Pimentel J" first="José" last="Pimentel">José Pimentel</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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